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Biogenics Research Institute
Other Respiratory Tract Disorders
Hypersensitivity Pneumonitis
Idiopathic Intersitial Lung Disease

Professional Curriculum Vitae
Untitled Document


  1. Name: Robert L. Jacobs, M.D.
  2. Biogenics Research Institute
    8255 Fredericksburg Road
    San Antonio TX 78229
           Biogenics Research Chamber
           8255 Fredericksburg Road
           San Antonio TX 78229


  1. Undergraduate Education
    a. School: University of Alabama
    b. Major: Biology
    c. Degree: Bachelor of Science
    d. Date: 1964
  3. Professional Education
    a. School: Medical College of Alabama
    b. Degree: M.D.
    c. Date: 1968
  5. Postgraduate Education
    a. Internship - July 1968 - June 1969, Malcolm Grow USAF Medical Center - Washington, D.C.
    b. Residency - July 1969 - June 1971, Wilford Hall USAF Medical Center - San Antonio, TX
    c. Fellowship - July 1971 - June 1973, Wilford Hall USAF Medical Center - San Antonio, TX


  1. Professional Licensure
    a. Alabama, #6216, 20Apr73.
    b. Texas, #E1627, 4Dec73
  3. Specialty Board Certification
    a. Medicine, # 100176, 15 Jul 69
    b. Internal Medicine, 39117, 19 Jun 74
    c. Allergy & Immunology, 1204, 21 Oct 75
  5. Recertification
    a. Allergy & Immunology
    b. Certificate # 291
    c. Date 3 Oct 83


  1. Academy of Pharmaceutical Physicians and Investigators
  3. Society of Medical Consultants to the Armed Forces
  5. American Academy of Allergy, Asthma and Immunology
  7. American College of Allergy
  9. Bexar County Medical Society
  1. Staff Allergist
    Department of Allergy and Immunology
    Wilford Hall USAF Medical Center, 1973 - 1974
  3. Chairman
    Department of Allergy and Immunology
    Wilford Hall USAF Medical Center, 1974 - 1984
  5. Training Program Director
    Department of Allergy and Immunology
    Wilford Hall USAF Medical Center, 1974 - 1984
  7. Associate Professor of Medicine
    Uniformed Services University of the Health Sciences, 1980 - 1984
  9. Clinical Assistant Professor of Medicine
    UT Health Science Center at San Antonio, 1980 - 1992
  11. Clinical Associate Professor of Medicine
    UT Health Science Center at San Antonio, 1993 - 2000
  13. Consultant to the Surgeon General in Internal Medicine Allergy and Immunology, 1977 - 1984
  15. Special Assistant to the Surgeon General
    1979 - 1984
  17. Colonel (Ret)
    USAF MC, 1984
  19. Chairman Scientific Program, Southwest Allergy Forum, 1985
  21. Associate Scientist, Department of Virology and Immunology,
    Southwest Foundation for Biomedical Research, 1985 - 1994
  23. Reviewer
    Annals of Internal Medicine, 1980 - present 

  24. Private Practice
    Allergy/Immunology, San Antonio, Texas 1984 - present   

  25. President and CEO
    Immunobionomics Laboratories, Inc. 1989 - 2007
  27. Medical Director/Principal Investigator
    Biogenics Research Institute, 1993 - present
  29. Sub Investigator
    Biogenics Research Institute, 2001 � present  
  30. Awards
    2009 Lifetime Achievement Award by San Antonio Business Journal

  31. Principal Investigator/CEO
    Biogenics Research Chamber, 2010-present
  19.  Awards
        2012 Lifetime Achievement Award by Bexar County Medical Society


  1. Stern MP, Jacobs RL, Duncan GW: Complete heart block complicating hyperthyroidism. JAMA 1970;212:2117-20

  2. Michels MI, Jacobs RL: Hypersensitivity to tetanus toxoid. J Allergy Clin Immunol 1974;53:118-9

  3. James FK, Pence HL, Driggers DJ, Jacobs RL, Horton DE: Imported fire ant sensitivity. Studies of human reactions to fire ant venom. J Allergy Clin Immunol 1976;58:110-20

  4. Dorman SG, Ruark GW, Agus ZS, Jacobs RL, Young R: Transient diabetes insipidus with elevated serum osmolarity associated with a benign febrile illness. Arch Int Med 1977;137:1479-81

  5. Jacobs RL, Freedman PM, Boswell RN: Non-allergic rhinitis with eosinophilia (NARES) syndrome. Clinical and immunological characterization. J Allergy Clin Immunol 1981;67:253-62

  6. Jacobs RL: A practical classification of chronic rhinitis. J Respir Dis 1981;2 (5):20
  8. Jacobs RL, Rake GW, Fournier DC, Chilton RJ, Culver WG, Beckmann CH: Potentiated anaphylaxis in patients with drug-induced beta-adrenergic blockade. J Allergy Clin Immunol 1981,68:125-27

  9. Jacobs RL, Lowe RS, Lanier BQ: Adverse reactions to tetanus toxoid. JAMA 1982;247:40-2

  10. Jacobs RL, Lowe RS, Lanier BQ: Unerwunschte reaktionen auf tetanustoxoid. JAMA - D 1982;1 (7):383-6

  12. Jacobs RL, Koppes GW: Myocardial necrosis associated with isoproterenol abuse: A ten year follow-up. Tex Med 1982;78:58-60

  13. Jacobs RL, Rake GW, Fournier DC, Chilton RJ, Culver WG, Beckmann CH: Glucagon in anaphylaxis - reply. J Allergy Clin Immunol 1982;69:331-32

  14. Nelson BL, Jacobs RL: Response of the non-allergic rhinitis with eosinophilia (NARES) syndrome to 4% cromolyn sodium nasal solution. J Allergy Clin Immunol 1982;70:125-28

  15. Strom GB, Boswell RN, Jacobs RL: In vivo and in vitro comparison of fire ant venom and fire ant whole body extract. J Allergy Clin Immunol 1983;72:46-53

  16. Rake GW, Jacobs RL: Anaphylactoid reactions to tolmetin and zomepirac. Ann Allergy 1983;50:323-25

  17. Jacobs RL, Freda AJ, Culver WG: Primary nasal polyposis. Ann Allergy 1983;51:500-05

  18. Jacobs RL: Reactions to tetanus toxoid. JAMA 1983;250:1273-74

  19. Hallett JS, Jacobs RL: Recurrent bronchitis: Therapy as usual? J Respir Dis 1984;5:80

  20. Jacobs RL, Lux GK, Spielvogel TL, Eichberg JW, Gleiser CA: Nasal polyposis in a chimpanzee. J Allergy Clin Immunol 1984;74:61-3

  21. Sacha RF, Tremblay NF, Jacobs RL: Chronic cough, sinusitis, and hyperactive airways in children: An often overlooked association. Ann Allergy 1985;54:195-98

  22. Hallett JS, Jacobs RL: Recurrent acute bronchitis: The association with undiagnosed bronchial asthma. Ann Allergy 1985;55:568-70

  23. Anderson DC, Schmalsteig FC, Finegold MJ, Hughes BJ, Rothlein R, Miller LJ, Kohl S, Tosi MF, Jacobs RL, Waldrop TC, Goldman AS, Shearer WT, Springer TA: The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: Their quantitative definition and relation to leukocyte dysfunction and clinical features. J Inf Dis 1985;152:668-89

  24. Jacobs RL, Patterson R: Immunotherapy v Pharmacotherapy for allergy sufferers. Respir Med Today 1986;2 (3):4-14

  25. Jacobs RL, Thorner RE, Holcolm JR, Schwietz LA, Jacobs FO: Hypersensitivity pneumonitis caused by Cladosporium in an enclosed hot-tub area. Ann Int Med 1986;105:204-06

  27. Halsey AB, Martin ME, Ruff ME, Jacobs FO, Jacobs RL: Sunflower oil is not allergenic to sunflower seed-sensitive patients. J Allergy Clin Immunol 1986;78:408-10.

  28. Waldrop TC, Anderson DC, Schmalstieg FC, Hallmon WW, Jacobs RL: Peridontol manifestations of the heritable Mac-1, LFA-1 deficiency syndrome-Clinical, histopathologic, and molecular characteristics. J Peridontol 1987;58:400-16

  29. Jacobs RL: Non-allergic chronic rhinitis syndromes. Immunol Allergy Clin North Amer 1987;7:93-103

  30. Jacobs RL, O'Gorman LA, Jacobs, FO: Environmentally-induced "asthma". J Allergy Clin Immunol 1987;79:140 (Abst. #61)

  31. Jacobs RL, Andrews CP, Jacobs FO: Hypersensitivity pneumonitis treated with an electrostatic dust filter. Ann Int Med 1989;110:115-18

  32. Jacobs RL, Meltzer EO, Selner JC, Slavin RG: Rhinitis: Not just hay fever. Patient Care 1989;23 (6);168-84

  33. Jacobs RL, Hoberman LJ, Goldstein HM: Angioedema of the small bowel caused by an angiotensin-converting enzyme inhibitor. Amer Jour Gastroen

  34. Jacobs RL, Hoberman LJ, Goldstein HM: Angioedema of the small bowel caused by an angiotensin-converting enzyme inhibitor. Amer Jour Gastroen 1994;89:1118 (letter)

  35. Jacobs RL, Andrews CP, Coalson J: Organic antigen-induced interstitial lung disease: Diagnosis and management. Ann Allergy Asthma Immunol 2002:88:30-41.

  36. Jacobs RL: Hypersensitivity Pneumonia: UIP/IPF histopathological presentation. J Allergy Clin Immunol 2002;110:532-533.

  37. Ratner PH, Howland WC, Jacobs RL, et al: Relief of Sinus Pain and Pressure with Fluticasone Propionate Aqueous Nasal Spray: A Placebo-Controlled Trial in Patients with Allergic Rhinitis. Allergy and Asthma Proc. 2002;23:259-263.

  38. Gross G, Jacobs RL, Woodworth TH, et al: Comparative efficacy, safety, and effect on quality of life of triamcinolone acetonide and fluticasone propionate aqueous nasal sprays in patients with fall seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2002;89:56- 62.

  39. McClusky OE, Bonham R, Fawcett W, Holcomb J, Jacobs R, Lanier B, Yates R: Black mold and human illness. Texas Med. 2002; 98:53-56.

  40. Jacobs RL, Andrews CP: Hypersensitivity pneumonia - NSIP histopathological presentation: A study in diagnosis and long-term management. Ann Allergy Asthma Immunol. 2003; 90: 265-270.

  41. Bardana EJ, Chapman JA, Charlesworth EN, Jacobs RL, Terr AI: Crossing over to the dark side of the mold issue: A dissenting view. Ann Allergy Asthma Immunol. 2003;91: 212-213 (letter).

  42. Chapman JA, Terr AI, Jacobs RL, Charlesworth EN, Bardana EJ: Toxic mold: phantom risk vs. science. Ann Allergy Asthma Immunol. 2003; 91: 222-232.

  43. Pauweis RA, Pedersen S, Busse WW, et al: Early intervention with budesonide in mild persistent asthma: a randomized, double-blind trial. Lancet. 2003 Mar 29; 361 (9363): 1071-6.

  44. Jacobs RL, Andrews CP, Coalson JJ: Hypersensitivity Pneumonitis: Beyond classic occupational disease-changing concepts of diagnosis and management. Ann Allergy Asthma Immunol. 2005;95: 115-128.

  45. O'Byrne PM, Pedersen S, Busse WW, et al: Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. Chest. 2006 Jun; 129(6): 1478-85

  46. Busse WW, Pedersen S, Pauwels RA, et al. The inhaled steroid treatment as regular therapy in early asthma (START) study 5 year follow-up; effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol. 2008;121:1167-74.

  47. Jacobs RL. Hypersensitivity pneumonitis may be home-induced by common domestic mold spores. J Allergy Clin Immunol. 2008;122:428.

  48. Jacobs RL, Lieberman P, Kent E, et al. Weather/temperature-sensitive vasomotor rhinitis may be refractory to intranasal corticosteroid treatment. Allergy Asthma Proc. 2009; 30 120-127.

  49. Andrews CP, Martin BG, Jacobs RL, et al: Fluticasone furoate nasal spray is more effective than fexofenadine for nighttime symptoms of seasonal allergy. Allergy Asthma Proc 2009; 30:128-138.

  50. Jacobs RL, Martin B, Hampel F, et al. Effectiveness of fluticasone furoate 110 micrograms once daily in the treatment of nasal and ocular symptoms of seasonal allergic rhinitis in adults and adolescents sensitized to mountain cedar pollen. Current Medical Research and Opinion. 2009;25:1393-140

  51. Ratner P, Jacobs R, Mohar D, et al. Evaluation of the efficacy and safety of  ciclesonide hydrofloride nasal aerosol 80 mcg or 160 mcg once daily for the seasonal allergic rhintis. Ann Allergy Asthma Immunol. 2010;105(6):471-9.

  52. Jacobs RL, Ramirez DA, Andrews CP. Validation of the Biogenics Research Chamber for Juniperus Ashei (mountain cedar) pollen. Ann Allergy Asthma Immunol. 2011;107:133-8.

  53. Jacobs RL. Ciclesonide for the treatment of seasonal allergic rhinitis. Expert Reviews of Clinical Immunology. 2011;7(6):735-41.

  54. Meltzer EO, Jacobs RL, LaForce CF, et al. Safety and efficacy of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with perennial allergic rhinitis. Allergy Asthma Proc. 2012;33:1-9.

  55. Jacobs RL, Harper N, Weijing H, et al. Responses to ragweed pollen in an environmental chamber versus seasonal exposure identifies allergic rhinoconjunctivitis endotypes. J Allergy Clin Immunol. 2012;130: 122-7.

  56. Andrews CP, Ratner PH, Ehler BR, et al. The mountain cedar model in clinical trials of seasonal allergic rhinoconjunctivitis. Ann Allergy Asthma Immunol. 2013:111:9-13.

  57. Ramirez RM, Jacobs RL. Eosinophilic esophagitis treated with immunotherapy to dust mites. J Allergy Clin Immunol. 2013;132:503-4.

  58. Jacobs RL, Harper N, He W, et al. Effect of confounding cofactors on responses to pollens during natural season versus pollen challenge chamber exposure. J Alergy Clin Immunol. 2014;133:1340-6.

  59. Ramirez RM, Jacobs RL. Hypersensitivity pneumonitis by Fusarium vasinfectum in a home environment. J Allergy Clin Immunol - In Practice. 2014;2 (4):483-4.

  60. Ratner P, Van Bavel J, Mohar D, Jacobs RL, Hampel F, Howland W, Karwai R. Efficacy of daily intranasal fluticason propionate on ocular symptoms associated with allergic rhinitis. Ann Allergy Asthma Immunol. 2015;114:141-7.

  61. Ramirez DA, Andrews CP, Rather CG, Jacobs RL. Participants sensitized to subtropical grasses respond to Timothy grass pollen in an allergen challeng chamber. Ann Allergy Asthma Immunol. 2015;114:839-46.

  62. Jacobs RL, Andrews CP, Ramirez DA, Rather CG, Harper N, Jimenez F, et al. Symptom dynamics during repeated, serial allergen challenge chamber exposures to house dust mite. J Allergy Clin Immunol. 2015;135:(4):1071-5.

  63. He W, Jimenez F, Martinez H, et al. Cockroach sensitization mitigates allergic rhinoconjunctivitis symptom severity in house dust mite and pollen allergic individuals. J Allergy Clin Immunol. 2015 (In Press)

  64. Berger WE, Jacobs RL, Amar NJ, Tantry SK, Li J, Small CJ. Efficacy and Safety of beclomethasone dipropionate nasal aerosol in children with perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2015;115:137-42.


  1. Hypersensitivity Pneumonitis: The View from the Front. Presented to the Colorado Allergy Society. October, 2005
  2. Hypersensitivity Pneumonitis: Are Diagnostic Criteria Too Restrictive? Presented at Allergy/Immunology Grand Rounds, National Jewish and Univ of Colorado. October, 2005
  3. Home Related Hypersensitivity Pneumonitis. Presented at the 4th International WASOG Conference on Diffuse Lung Disease. Tokyo, Japan. October, 2007.